What you get
A structured evidence pack spanning four literatures that rarely sit together: clinical efficacy, burden of illness, economic evaluation, and real-world outcomes — each section cited, with the gaps named.Who it’s for
HEOR and market access teams building reimbursement submissions, and the consultancies who build them on their behalf.Why this one is awkward
Payer dossiers span clinical and economic literature that use different vocabularies, sit in different journals, and are indexed under different fields. A single query returns one of them and misses the rest. The fix is running four deliberately separate searches and keeping them separate in the output.The four searches
country when the submission is to a specific national payer — cost-effectiveness evidence is jurisdiction-dependent, and a US cost-per-QALY carries little weight with a European HTA body.
The prompt
Audit requirements
Follow the grounding rules. Log the four search sets separately with their counts. If a section returned little — economic evaluations are frequently sparse for newer products — that sparsity is a finding a payer will also notice, so report it rather than padding.What to check before you trust it
- Check jurisdiction on every economic study. Cost-effectiveness does not transfer across health systems, and a reviewer will spot a mismatched threshold immediately.
- Check currency and year. Costs from a decade ago in another currency need conversion and inflation adjustment before they mean anything.
- Read the gap section first. Where the evidence is thin is exactly where the payer will push, so it is the most useful output.
- Real-world and trial evidence disagreeing is normal. Explain the gap rather than presenting only the flattering one.
Related
Monitor new research about a drug, device, or brand
Keep watching the evidence base after submission.
Grade a set of papers with your own evidence rubric
Score the evidence you assemble consistently.
Best practices
Fan-out and merge, and the rest of the primitives.
All use cases
Browse the gallery by persona.